Lipedema and Chronic Inflammation

Lipedema is a chronic disease of lipid metabolism that results in symmetrical impairment of fatty tissue distribution and storage combined with the hyperplasia of individual fat cells causing edema, lipolymphedema.

Lymphatic dysfunction produces interstitial edema and immune dysfunction causing chronic inflammation. Lymphatic dysfunction and chronic inflammation are potential therapeutic targets aiming reduce or modulate the progression of this condition.

Chronic inflammation is not only present in lipedema but in other conditions such as cardiovascular disease, metabolic syndrome, obesity, diabetes, inflammatory bowel disease, malignancy, autoimmune disorders, etc.

Chronic inflammation indicators such as elevated complement total activity (CH50), c-reactive protein (CRP) and interleukin 6 (IL-6) may be present in lipedema.

An elevated CH50 indicates high level of activity of the classical pathway of the complement system suggesting the presence of active inflammation and immune activation. C-reactive protein (CRP) is a substance produced by the liver that increases in the presence of inflammation in the body. Interleukin-6 (IL-6) is an endogenous chemical which is active in inflammation, and in B cell maturation.

How to reduce chronic inflammation:

  • get enough sleep
  • low impact aerobic and strengthening exercises to improve fitness level
  • reduce stress
  • reduce alcohol and caffeine consumption
  • improve gastrointestinal  function
  • reduce trans fat, refined sugars, dairy and gluten intake
  • eat omega-3 rich foods, fresh fish like wild salmon, extra virgin olive oil, organic free range chicken, whole grains, raw vegetables, dark leafy greens, peppers, berries, nuts, low fat unsweetened yogurt, ginger, turmeric, garlic, citrus, jasmine green tea
  • eliminate known allergens and food preservatives

Getting healthy – small changes makes a big difference!